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HIV-infected individuals receiving ART should be treated with a 9-month regimen of INH.

With macrolides, a shorter length of therapy seems acceptable.

Bacteriologic smears or cultures should be obtained before the start of therapy to confirm the susceptibility of the organism to rifampin, isoniazid, and pyrazinamide and they should be repeated throughout therapy to monitor response to the treatment.

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Exceptions may be disseminated disease, and meningitis, for which there are inadequate data to support 6-month therapy.

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Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in Tunisian patients with tuberculosis.

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Treatment of all forms of active tuberculosis caused by susceptible organisms and as preventive in high-risk persons (e.

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The lifetime risk varies from 17 percent among children 0 to 5 years of age who have induration of 15 mm or more on the skin test to 2 percent in the oldest cohort.

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Empirical treatment with a four-drug regimen should be initiated promptly when a patient is seriously ill with a disorder that is thought possibly to be tuberculosis.

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The diagnosis of acute liver failure requires the finding of liver test abnormalities indicative of acute liver injury, accompanied by signs or symptoms of hepatic encephalopathy in a patient with no known previous liver injury.

We used Cox proportional models to compare outcomes between the deferred-ART and early-ART strategies and between the IPT and no-IPT strategies.

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In addition, the results of our recently published long-term study indicate that pulmonary tuberculosis occurred throughout the 5-year study period and further support the efficacy of isoniazid with antiretroviral therapy for the prevention of tuberculosis.

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Trials of anti-tuberculosis treatment as a diagnostic tool in smear-negative tuberculosis are of questionable benefit".

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Mild side effects include red, orange, or brown discoloration of skin, tears, sweat, saliva, urine, or tools, which is a harmless but potentially alarming side effect if the patient is not forewarned; nausea and loss of appetite; stomach pain; mild skin rash or itching; headache; and joint pain.

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Interactions Affecting Antituberculosis Drugs.

Clinicians also should be aware that patients with end-stage renal disease may have additional clinical conditions, such as diabetes mellitus with gastroparesis, that may affect the absorption of the antituberculosis drugs, or they may be taking concurrent medications that interact with these drugs.

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Vitamin C (100 to 200 mg per day): Several studies suggest that eating a diet high in vitamin C can help lower cholesterol levels, but there is no evidence that taking extra vitamin C through a supplement will help.

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Isoniazid is chemically known as isonicotinyl hydrazine or isonicotinic acid hydrazide.

HIV-infected patients: safety and antiretroviral efficacy of the concomitant use of ritonavir and rifampin.

Since the bacteria may exist in a resting (nongrowing) state for long periods, therapy with isoniazid (and other antituberculosis drugs) must be continued for a long time (usually 6 to 12 months).

Medications that injure non-parenchymal and endothelial cells in the liver can cause a sinusoidal obstruction syndrome, also known as veno-occlusive disease.

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Furthermore, caregiver self-reports were often difficult to obtain as the children arrived for study visits with a variety of caregivers, many of whom could not provide information on how medication had been taken in the previous week.

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WHO-recommended TB control strategy known as DOTS.

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Kenneth Castro discussing CDC guidelines for the use of a new regimen for the treatment of persons with LTBI.

The bacillus is generally sensitive to isoniazid, pyrazinamide, paraaminosalicylic acid, streptomycin, rifampin, ethambutol, dihydrostreptomycin, ultraviolet radiation, and heat.

The right forearm of a client who had a purified protein derivative (PPD) test for tuberculosis is reddened and raised about 3mm where the test was given.

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To maintain optimum therapeutic blood levels, dosages of drugs metabolized by these enzymes may require adjustment when starting or stopping concomitantly administered rifampin.

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Because there are less bacteria, treatment for latent TB infection is much easier than treatment for TB disease.

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