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Aspirin (Bayer, Bufferin, Excedrin), ibuprofen (Motrin, Advil), or naproxen (Alleve, Nuprin) can be effective migraine therapies in some patients.

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Discontinue drug in patients with persistent QTc measurements of more than 500 ms.

Some doctors have used small amounts of L-tryptophan in combination with SSRIs, to increase the effectiveness of the latter.

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Slow inhibitory neurotransmission is mediated by the GABAB receptor (GABABR), a metabotropic receptor coupled to various effector systems (G proteins, inwardly-rectifying potassium channels, etc).

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Its mechanism of action is unknown, but it increases the concentration of serotonin and norepinephrine in the CNS by inhibiting their reuptake by presynaptic neuronal membrane.

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Format switch: There are three distinct formats of zolmitriptan engineered for the treatment of migraines including: oral tablet, orally disintegrating tablet, and nasal spray.

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APF530 contains the 5-HT3 antagonist, granisetron, formulated using the proprietary Biochronomer drug delivery system, which allows therapeutic drug levels to be maintained for five days with a single subcutaneous injection.

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However, because of the potential for side effects, 5-HTP and L-tryptophan should never be taken in combination with citalopram or other SSRIs, unless a doctor is closely monitoring the combination.

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There are few reports of ergotism among patients taking doses within the recommended limits or for brief periods of time.

The drug was approved for use in the by the on December 3, 2010.

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It is usually administered in conjunction with antiemetics such as metoclopramide, which is a 5HT3-receptor antagonist and a dopamine antagonist, to treat migraine-associated nausea.

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