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Is divalproex a cost-effective alternative in the acute and prophylactic treatment of bipolar I disorder: Reply: Journal of Clinical Psychiatry Vol 58(11) Nov 1997, 496.

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Lithium - so my doc is transitioning me to Lamictal, which is supposed to have the least amount of side effects - especially weight gain.

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In some cases, the effect of a barbiturate could increase to toxic levels while the potency of Depakote could decrease, making the medicine ineffective.

Keep in n mind I have no major problems like some people that have posted ( seizures or brain surgery etc ) and I would never try to stop this medicine if that were the case.

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No other drug to date has controlled my seizures, i've lost all my jobs no matter how hard i try i get sick, due to my lost job i have no healthcare, and to end on a great note my one hope at trying to get better SSI has denied me over and over even though my doctor always wanted me to go on it i wouldn't do it and now that i need to they seem to think i'm fine just cause i didn't go to hospitals when i seized or got sick (since i had no health coverage) so yea alotta double negatives going on.

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Yes, I did have slight weight gain, and yes it did affect my ability to perform sexually, but I did not have to continue taking it for more than 3 months.

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Jerry Kennard, psychologist and Associate Fellow and Chartered member of the British Psychological Society, provides some expertise and insight into the diagnosis and treatment of Bipolar Disorder.

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It definitely DID HELP my rapid cycling but turned me into a zombie with terrible side effects that caught up to me.

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Women who are already pregnant and taking high doses of valproate should try to lower their doses.

Along with your condition and the fact that this drug may cause reduced alertness add to that alcohol which may increase the sedative effect of valproate, such things as driving, hazardous, work and alcohol should be avoided.

The capacity of elderly patients (age range: 68 to 89 years) to eliminate valproate has been shown to be reduced compared to younger adults (age range: 22 to 26).

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In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for anti-seizure activity.

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